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KMID : 0389420100180030275
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Korean Journal of Stress Research
2010 Volume.18 No. 3 p.275 ~ p.285
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The Effect of Stress on the Changes of B-type Natriuretic Peptide Expression and HRV in Myocardial Infarction Model Rats
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Lee Sam-Youn
Lee Mi-Kyoung
Kim Nam-Ho
Joo Min-Cheol
Jo Hyang-Jeong
Kang Ji-Sook
Kim Byung-Sook
Yoon Sun-Sik
Choi Eul-Sig
Lee Moon-Young
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Abstract
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Diminished heart rate variability (HRV) is associated with less favorable prognosis after myocardial infarction (MI). It has been reported that very low frequency (VLF) power in HRV analysis is an independent risk predictor in patients with congestive heart failure and B-type natriuretic peptide (BNP) can be used as a prognostic factor of MI. The purpose of this study was to investigate whether stress has an effect to the changes of BNP expression and/or heart rate variability in MI model in rats. Male Sprague-Dawley rats were divided into 3 groups: control group (CON), MI group (MI＋No Stress), and MI followed by stress group (MI＋Stress). MI＋Stress group rats were raised for a two month recovery period after the operation, followed by being exposed to restraint stress for 2 hours per day for 1 week. Electrocardiogram was recorded after the operation and the last day after 1 week of stress. The frequency components of HRV were calculated in the frequency domain such as VLF, low frequency (LF), high frequency (HF) and so on. In HRV analysis, standard deviation of the normal to normal intervals (SDNN) was significantly reduced in both groups compared to the control group. VLF and LF also were significantly reduced in MI＋Stress group compared to the control groups. In addition, BNP expression in western blotting was shown the strongest bands in MI＋Stress group among experimental groups. These results suggest that BNP and HRV were aggravated by stress in MI rat model.
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KEYWORD
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Stress, Myocardial infarction model, Heart rate variability, B-type natriuretic peptide
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